Table 3.
Slope coefficients and SE from mixed effects substantive model (random intercepts and slopes) with global cognitive score outcome and 5% of participants with informative attrition
| Observed in Whitehall II study | Full simulated data | Estimation method | Estimation method | |||||
|---|---|---|---|---|---|---|---|---|
| Available case | MI | PMM | Available case | MI | PMM | |||
| Impute smokinga | Impute educationa | |||||||
| Coefficient (SE) | ||||||||
| Reference | − 0.3120 | − 0.3120 (0.0095) | − 0.3082 (0.0139) | −0.3026 (0.0141) | − 0.3401 (0.0153) | − 0.3090 0.0133) | − 0.2885 (0.0104) | − 0.3240 (0.0119) |
| Smoking status | ||||||||
| Ex-smoker | −0.3271 | − 0.3272 (0.0096) | − 0.3236 (0.0142) | − 0.3208 (0.0145) | − 0.3710 (0.0159) | − 0.3244 (0.0135) | − 0.3040 (0.0108) | − 0.3377 (0.0123) |
| Current smoker | −0.4228 | − 0.4229 (0.0110) | − 0.4185 (0.0159) | − 0.3970 (0.0162) | − 0.4558 (0.0176) | −0.4190 (0.0156) | − 0.3975 (0.0131) | −0.4447 (0.0152) |
| Age Category (year) | ||||||||
| 50 and < 55 | −0.3619 | −0.3619 (0.0091) | − 0.3577 (0.0135) | −0.3510 (0.0138) | − 0.3925 (0.0151) | −0.3585 (0.0129) | − 0.3377 (0.0100) | −0.3779 (0.0117) |
| 55 and < 60 | − 0.4400 | −0.4398 (0.0093) | −0.4350 (0.0139) | − 0.4262 (0.0142) | − 0.4789 (0.0156) | − 0.4359 (0.0132) | − 0.4133 (0.0105) | − 0.4644 (0.0124) |
| 60 and < 65 | − 0.5029 | −0.5029 (0.0095) | −0.4971 (0.0154) | − 0.4824 (0.0158) | − 0.5517 (0.0170) | − 0.4984 (0.0148) | − 0.4700 (0.0128) | − 0.5390 (0.0145) |
| 65 | −0.5699 | − 0.5703 (0.0108) | −0.5648 (0.0419) | − 0.5382 (0.0417) | −0.5717 (0.0425) | − 0.5637 (0.0433) | −0.5204 (0.0433) | − 0.5588 (0.0438) |
| Employment grade | ||||||||
| Intermediate | −0.2481 | −0.2483 (0.0091) | −0.2434 (0.0135) | − 0.2358 (0.0137) | − 0.2928 (0.0151) | − 0.2443 (0.0126) | − 0.2237 (0.0100) | − 0.2805 (0.0117) |
| Low | − 0.2178 | − 0.2173 (0.0129) | − 0.2093 (0.0198) | − 0.1974 (0.0200) | − 0.2963 (0.0226) | −0.2096 (0.0189) | − 0.1857 (0.0178) | −0.2870 (0.0208) |
| Education | ||||||||
| School | −0.3222 | −0.3223 (0.0052) | − 0.3214 (0.0063) | −0.3198 (0.0064) | − 0.3260 (0.0068) | −0.3213 (0.0059) | − 0.3165 (0.0059) | −0.3274 (0.0063) |
| University | −0.3232 | − 0.3232 (0.0043) | − 0.3229 (0.0051) | − 0.3224 (0.0052) | − 0.3220 (0.0055) | − 0.3229 (0.0052) | − 0.3241 (0.0051) | − 0.3304 (0.0054) |
MI multiple imputation, PMM pattern mixture modelling
aMissing global cognitive function scores also imputed