Table 1.

Inhibition of NS2/3 by HSP90 inhibitors

NS2/3 processing reactions were performed with 810–1615BK. The inhibitory effects of geldanamycin and radicicol were titrated as described previously for peptide inhibition titrations (17). For both inhibitors, inhibition leveled out at the maximum extent indicated in the table so that an effective concentration (EC₅₀) is used to describe the relative potency (see Materials and Methods). Values given are the average of two determinations.