Table 2.

Correlation of Cyclin D1, SOX2, and p53 expression with clinicopathological features in 117 ESCC patients

Characteristic	Cyclin D1		p-value	SOX2		p-value	P53		p-value
	Low	High		Low	High		Low	High
Gender
Male	30	57		48	39		41	46
Female	5	25	0.104	15	15	0.674	12	18	0.531
Age (years)
<65	21	47		39	29		33	35
≥65	14	35	0.840	24	25	0.453	20	29	0.455
Tumor size
<4 cm	25	60		47	38		37	48
≥4 cm	10	22	0.825	16	16	0.679	16	16	0.540
Differentiation
Well	4	10		13	1		7	7
Moderate	18	47		28	37		30	35
Poor	13	25	0.779	22	16	0.003	16	22	0.861
Lymph node
Absent	19	55		41	33		35	39
Present	16	27	0.213	22	21	0.703	18	25	0.569
N stage
N0	19	55		42	32		35	39
N1	7	18		9	16		12	13
N2	6	6		6	6		4	8
N3	3	3	0.247	6	0	0.034	2	4	0.745
Pathological stage
T1	2	3		2	3		4	1
T2	15	40		27	28		23	32
T3	18	39	0.778	34	23	0.436	26	31	0.259
Venous invasion
Absent	26	63		46	43		39	50
Present	9	19	0.815	17	11	0.515	14	14	0.665
Perineuronal invasion
Absent	26	61		46	41		38	49
Present	9	21	1.000	17	13	0.833	15	15	0.671
LNR
<0.2	26	70		50	46		44	52
≥0.2	9	12	0.190	13	8	0.475	9	12	1.000
P53
Low	22	31		27	26
High	13	51	0.015	36	28	0.582
Ki-67
Low	25	54		51	28		41	38
High	10	28	0.668	12	26	0.001	12	26	0.048
pTNM
I	11	24		18	17		18	17
II	8	26		16	18		18	16
III	13	15		19	9		8	20
IV	3	17	0.091	10	10	0.385	9	11	0.213
Therapy
Surgery	24	52		40	36		34	42
Chemotherapy	7	23		17	13		15	15
Radiotherapy	3	6	0.681	4	5	0.806	2	7	0.337

Abbreviations: ESCC, esophageal squamous cell carcinoma; LNR, lymph node ratio.