Table 3.
Univariate analysis of factors associated with OS and PFS in ESCC patients
| Characteristic | OS
|
PFS
|
||
|---|---|---|---|---|
| χ2 | p-value | χ2 | p-value | |
| Gender | ||||
| Male/female | 0.381 | 0.537 | 0.314 | 0.575 |
| Age, years | ||||
| ≥65/<65 | 2.453 | 0.117 | 0.291 | 0.590 |
| Size, cm | ||||
| ≥4/<4 | 2.694 | 1.101 | 0.465 | 0.495 |
| Differentiation | ||||
| Poor/moderate/well | 0.278 | 0.870 | 0.080 | 0.961 |
| Pathological stage | ||||
| T1/T2/T3 | 0.897 | 0.639 | 0.611 | 0.737 |
| Venous invasion | ||||
| Present/absent | 5.953 | 0.015 | 1.751 | 0.186 |
| Perineuronal invasion | ||||
| Present/absent | 3.080 | 0.079 | 0.805 | 0.370 |
| Lymph metastasis | ||||
| Present/absent | 7.172 | 0.007 | 3.264 | 0.052 |
| N stage | ||||
| N0/N1/N2/N3 | 10.623 | 0.014 | 1.863 | 0.601 |
| Involved LNR | ||||
| ≥0.2/<0.2 | 3.441 | 0.064 | 0.107 | 0.743 |
| Therapy | ||||
| Surgery/chemotherapy/radiotherapy | 6.233 | 0.044 | 0.265 | 0.876 |
| pTNM | ||||
| I/II/III/IV | 12.316 | 0.006 | 28.801 | 0.0001 |
| Ki-67 | ||||
| Low/high | 0.779 | 0.378 | 0.139 | 0.709 |
| P53 | ||||
| Low/high | 5.623 | 0.018 | 7.621 | 0.006 |
| Cyclin D1 | ||||
| Low/high | 1.412 | 0.235 | 0.933 | 0.334 |
| SOX2 | ||||
| Low/high | 5.291 | 0.021 | 1.477 | 0.224 |
| P53 + Cyclin D1 | ||||
| Low/high | 3.949 | 0.047 | 11.470 | 0.001 |
| P53 + ki-67 | ||||
| Low/high | 0.040 | 0.841 | 2.080 | 0.149 |
Abbreviations: ESCC, esophageal squamous cell carcinoma; OS, overall survival; PFS, progression-free survival; LNR, lymph node ratio.