Table 1.
Clonality of p53 mutations in exon 8 of p53-immunopositive clones
Clone number | Codon | Normal sequence | Base change | Amino acid change |
---|---|---|---|---|
Normal | wt | |||
Normal | wt | |||
Normal | wt | |||
1 | 270 | gttCgt | C→T/wt | Arg→Cys |
2 | wt | |||
3 L | 270 | gttCgt | C→T/wt | Arg→Cys |
3 R | 270 | gttCgt | C→T/wt | Arg→Cys |
4 | 270 | gttCgt | C→T/wt | Arg→Cys |
5 | 270 | gttCgt | C→T/wt | Arg→Cys |
6 | wt | |||
7 L | wt | |||
7 R | wt | |||
8 | 271 | cgtGTTtgt | GTT→TGG/wt | Val→Trp |
9 | wt | |||
10 L | 270 | gttCgt | C→T/0 | Arg→Cys |
10 R | 270 | gttCgt | C→T/wt | Arg→Cys |
11 L | 270 | gttCgt | C→T/wt | Arg→Cys |
275 | tgccCt | C→T/wt | Pro→Leu | |
11 R | 270 | gttCgt | C→T/wt | Arg→Cys |
275 | tgccCt | C→T/wt | Pro→Leu | |
12 | wt | |||
13 | 270 | gttCgt | C→T/wt | Arg→Cys |
14 | 270 | gttCgt | C→T/0 | Arg→Cys |
15 L | 270 | gttCgt | C→T/0 | Arg→Cys |
15 R | 270 | gttCgt | C→T/0 | Arg→Cys |
16 L | 270 | gttCgt | C→T/0 | Arg→Cys |
16 R | 270 | gttCgt | C→T/0 | Arg→Cys |
17 | 270 | gttCgt | C→T/wt | Arg→Cys |
284 | gaaGaa | G→A/wt | Glu→Lys | |
18 | 270 | gttCgt | C→T/wt | Arg→Cys |
19 | 278 | agaGac | G→A/wt | Asp→Asn |
wt, wild type.