Fig. 4.

Receiver operating characteristic for all epigenetic variables. Receiver operating characteristic (ROC) were plotted for breast cancer status as the reference variable and age, DNAmAge, mean methylation by sample, age acceleration difference, and age acceleration residuals as classification variables. DeLong method was used to calculate the standard errors, and binomial confidence intervals were calculated. The ROC curves were plotted based on the binomial fit models, and the AUC was calculated. The sensitivity and specificity of the most predictive epigenetic variable was then calculated based on the ROC curve