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a-b, The acidic pocket (a) and canonical thumb domain Cl- binding site (b) of superposed resting and desensitized (grey) channels. c-e, Br- anomalous difference peak (green mesh) contoured at 5 σ and mapped on a resting channel at high pH (c) and detail views of the Br- binding site with (d) and without (e) surface representation. One anion site, of the three, is shown.
