Fig 6.

Effect of once daily i.p. administration of liraglutide, (Lys⁸GluPAL)apelin-13 amide or pGlu(Lys⁸GluPAL)apelin-13 amide (each at 25 nmol/kg bw) on O₂ consumption (A, B) and CO₂ production (C, D). Following 36-days of treatment mice were placed in CLAMS metabolic chambers for 24 h to acclimatise and a further 24 h for measurements (12 h dark period as shown by the black bar), O₂ consumption and CO₂ production were measured for 30 sec at 25 min intervals. Values represent the mean ± S.E.M. (n = 6) where *p<0.01 is compared to high-fat fed saline treated mice and ^▽▽p<0.01 is compared to normal mice.