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. 2018 Aug 29;37:204. doi: 10.1186/s13046-018-0859-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Chemotherapy-induced niche perturbs hematopoietic reconstitution of HSCs. a Experimental design to determine the hematopoietic reconstitution of LSK cells isolated from Ctrl+A2D and B-ALL+A2D. b Percentages of donor-derived cells after first competitive reconstitution. n = 5–6 mice per group. c Percentages of donor-derived cells after second transplantation. n = 5 mice per group. d Experimental design to determine the hematopoietic reconstitution of normal LSK-tomato⁺ cells isolated from the chemotherapy-induced niche of Ctrl+A2D and B-ALL+A2D. e Percentages of tomato⁺ cells after first competitive reconstitution. n = 5 mice per group. f Percentages of donor-derived cells after second transplantation. n = 5 mice per group. g Flow cytometric analysis of lineage differentiation of LSK in (b). All data in this figure were shown as mean ± SD from three separate experiments. * P ≤ 0.05; ** P < 0.01