Table 1. Patients and controls characteristics.
| HS n = 26 |
IBD in remission n = 24 |
Active IBD n = 25 |
|
|---|---|---|---|
| Sex (male) | 11 (42.3%) | 15 (62.5%) | 11 (44%) |
|
Age (years) (mean+/-SEM) |
35.4 +/-2.8 | 41.5 +/-2.5 | 35.6 +/- 2.5 |
| Smokers | 2* (7.7%) | 8 (32%) | 6 (24%) |
| Type of IBD | — | 12 UC (50%)/12 CD | 15 UC (60%)/10 CD |
|
Disease duration (years) (mean+/-SEM) |
— | 11.0+/-2.2 | 4.3+/-1.0* |
|
Disease location Montreal classification[26] |
— | CD: L1 (n = 3), L2 (n = 2), L3 (n = 7) p (n = 5) UC: E1 (n = 1), E2 (n = 6) E3 (n = 5) |
CD: L1 (n = 2), L2 (n = 6), L3 (n = 2) p (n = 6) UC: E1 (n = 1), E2 (n = 7), E3 (n = 7) |
|
Disease activity scores (mean+/-SEM) |
— | HBI: 1.7 +/-0.3 Mayo: 0.8+/-0.2 |
HBI: 9.2 +/-1.9** Mayo: 6.7+/-0.3*** |
|
CRP (mg/L) (mean+/-SEM) |
— | 4.5+/-1.2 | 49.1 +/-8.7*** |
|
Hemoglobin (g/dl) (mean+/-SEM) |
— | 13.7+/-0.4 | 11.8+/-0.4* |
| Treatment | — | CS (2), 5ASA(14), IS (9), Biologic (18) | CS (5), 5ASA(12), IS (5), Biologic** (7) |
* p < 0.05
**p < 0.005
***p < 0.001: p values vs the IBD group in remission
SEM: standard error of the mean
HS: healthy subject, IBD: inflammatory bowel diseases, UC: ulcerative colitis, CD: Crohn’s disease, HBI: Harvey Bradshaw index, CRP: C-reactive protein, CS: corticosteroids, 5ASA: 5-aminosalicylates, IS: immunosuppressive agent.