Table 2.
Associations between IgG glycan and blood lipids
| IgG glycans | Prin. 3 | Prin. 4 | ||
|---|---|---|---|---|
| β (95% CI)a | P | β (95% CI)b | P | |
| Initial measurements | ||||
| GP2 | 0.046 (0.006 to 0.087) | 0.023* | − 0.012 (− 0.055 to 0.032) | 0.596 |
| GP4 | 0.035 (0.014 to 0.056) | 0.001* | − 0.015 (− 0.039 to 0.010) | 0.237 |
| GP5 | 0.035 (0.014 to 0.055) | 0.001* | 0.019 (− 0.006 to 0.044) | 0.130 |
| GP6 | 0.036 (0.015 to 0.057) | < 0.001** | − 0.010 (− 0.034 to 0.014) | 0.395 |
| GP11 | 0.020 (0.004 to 0.036) | 0.013* | 0.017 (− 0.001 to 0.035) | 0.066 |
| GP14 | − 0.022 (− 0.037 to 0.006) | 0.006* | 0.004 (− 0.014 to 0.022) | 0.642 |
| GP18 | − 0.033 (− 0.051 to 0.015) | < 0.001** | 0.006 (− 0.015 to 0.026) | 0.604 |
| GP20 | 0.014 (− 0.015 to 0.042) | 0.336 | 0.051 (0.018 to 0.084) | 0.003* |
| GP21 | 0.024 (0.004 to 0.045) | 0.020* | 0.025 (0.001 to 0.049) | 0.041* |
| Sialylation | ||||
| FGS/(FG + FGS) | − 0.014 (− 0.025 to 0.003) | 0.013* | 0.001 (− 0.011 to 0.014) | 0.840 |
| FGS/(F + FG + FGS) | − 0.023 (− 0.037 to 0.008) | 0.003* | 0.006 (− 0.012 to 0.023) | 0.527 |
| Bisecting GlcNAc | ||||
| FBStotal/FStotal | 0.021 (0.002 to 0.041) | 0.032* | − 0.008 (− 0.030 to 0.014) | 0.498 |
| FBS2/FS2 | 0.020 (0.001 to 0.038) | 0.039* | 0.005 (− 0.016 to 0.023) | 0.660 |
| FBS2/(FS2 + FBS2) | 0.011 (0.001 to 0.020) | 0.034* | 0.002 (− 0.009 to 0.013) | 0.740 |
| Galactosylation | ||||
| G0n | 0.029 (0.012 to 0.046) | 0.001* | –0.013 (− 0.033 to 0.007) | 0.212 |
| G2n | − 0.026 (− 0.043 to 0.009) | 0.003* | 0.008 (− 0.013 to 0.027) | 0.476 |
Prin.1 = 0.773 × SBP + 0.783 × DBP + 0.575 × FBG + 0.106 × RHR + 0.352 × Age + 0.688 × BMI + 0.733 × WHR
Prin.2 = 0.361 × SBP + 0.364 × DBP − 0.176 × FBG + 0.739 × RHR − 0.370 × Age − 0.246 × BMI − 0.329 × WHR
Prin.3 = 0.985 × TC + 0.134 × TG + 0.444 × HDL + 0.923 × LDL
Prin.4 = 0.133 × TC + 0.889 × TG-0.755 × HDL + 0.092 × LDL
BMI body mass index, WHR waist–hip ratio, FBG fasting blood glucose, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG total triglycerides, HDL high-density lipoprotein, LDL low-density lipoprotein, RHR resting heart rate
aAdjusted for the effects of sex, Prin.1, Prin.2 and Prin.4
bAdjusted for the effects of sex, Prin.1, Prin.2 and Prin.3
* Statistically significant associations between two variables are shown, P < 0.05
** Statistically significant associations between two variables are shown, P < 0.05/57 = 0.0009