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. 2018 Jan 30;9(63):32134–32148. doi: 10.18632/oncotarget.24345

Figure 4. GLUR2 protein level but not mRNA was increased in the absence of Pum2.

Figure 4

(A–D) Immunofluorescent staining showed that GLUR2 signaling is much stronger in the mutant hippocampus (n = 3). (E) Western Blot analysis showed that GluR2 protein levels were significantly higher in the hippocampus of Pum2 mutant mice as compared to WT mice, as analyzed by the relative signal intensity of western blots from three different animals. Mean ± SEM, *p < 0.05. (F) mRNA expression of Glur2 is not different between wildtype and Pum2–/– mutant hippocampus, suggesting that the increased GLUR2 protein in Pum2–/– mutant likely resulted from posttranscriptional regulation via PUM2 (n = 3 for each genotype). *means p < 0.05. Data represent as mean ± SEM.