Table 3. Subgroup analysis.

	LVI	PNI	SVI	ECE	LNI	PSM
Overall	1.85 [1.54, 2.22]	1.59 [1.33, 1.91]	1.97 [1.79, 2.18]	2.03 [1.65, 2.50]	1.88 [1.37, 2.60]	1.79 [1.56, 2.06]
HR analysis
Univariate	2.73 [1.90, 3.94]	2.29 [1.92, 2.73]	3.61 [2.80, 4.66]	3.44 [2.63, 4.52]	6.09 [3.29, 11.27]	2.34 [2.09, 2.63]
Multivariate	1.85 [1.48, 2.33]	1.39 [1.12, 1.74]	1.93 [1.73, 2.14]	1.95 [1.61, 2.36]	1.88 [1.37, 2.60]	1.91 [1.66, 2.20]
Endpoint
Primary endpoint	2.05 [1.64, 2.58]	2.28 [1.62, 3.21]	2.21 [1.63, 2.99]	1.80 [0.26, 12.29]	/	/
Second endpoint	1.44 [1.18, 1.76]	1.38 [1.12, 1.72]	1.95 [1.76, 2.16]	2.03 [1.65, 2.51]	1.88 [1.37, 2.60]	1.79 [1.56, 2.06]
Area
Eastern	1.46 [1.24, 1.72]	1.50 [1.20, 1.88]	2.13 [1.73, 2.62]	2.03 [1.41, 2.92]	3.06 [1.79, 5.25]	1.91 [1.45, 2.52]
Western	2.26 [1.74, 2.93]	1.79 [1.31, 2.44]	1.93 [1.73, 2.16]	2.02 [1.58, 2.58]	1.73 [1.23, 2.43]	1.69 [1.53, 1.87]
Year of publication
≥ 2010	1.44 [1.16, 1.79]	1.85 [1.19, 2.87]	1.96 [1.75, 2.20]	2.01 [1.72, 2.34]	2.33 [1.98, 2.74]	1.70 [1.53, 1.89]
< 2010	2.00 [1.59, 2.50]	1.49 [1.14, 1.94]	1.99 [1.50, 2.63]	2.02 [1.38, 2.96]	1.62 [1.12, 2.35]	1.82 [1.56, 2.12]
Sample
> 300	1.72 [1.37, 2.16]	1.48 [1.18, 1.86]	1.96 [1.76, 2.18]	2.29 [1.75, 2.99]	1.44 [1.30, 1.58]	1.71 [1.55, 1.89]
≤ 300	1.95 [1.60, 2.37]	1.81 [1.34, 2.45]	2.04 [1.61, 2.57]	1.75 [1.27, 2.40]	2.04 [1.16, 3.60]	1.94 [1.43, 2.62]

LVI = lymphovascular invasion; PNI = perineural invasion; SVI = seminal vesicle invasion; ECE = extracapular extension; LNI = lymph node involvement; PSM = positive surgical margin.