Figure 5. Reduced cell viability in response to TRAIL depends on SOCS3 expression.

Cell viability after treatment with IFN-α and/or TRAIL were compared with non-treated cells. (A) ACHN cells seeded on a culture plate were transfected with an empty vector or pCI-SOCS3 vector. (B) 786-O cells were transfected with negative control siRNA or SOCS3 siRNA. Cell viability after TRAIL treatment changed in a SOCS3-dependent manner. ^*p < 0.05 for two-tailed paired t test compared with control.