Table 1. Patients and sample characteristics.
| Patient number | Age at diagnosis | Primary tumor molecular subtype | Primary tumor characteristics | TNM | Stage at diagnosis | Sites of relapse | Biopsy of the relapse | Relapse characterisitics |
|---|---|---|---|---|---|---|---|---|
| Patient 1 | 56 | LUMINAL A-like | CDI G3, ER 50%, PR 70%, MIB1 20%, HER2 negative | pT2pN1(3/17)M0 | IIB | SKIN (Local Relapse) | SKIN NODULE EXCISION | ER 100%, PR 20%, HER2 negative |
| Patient 2 | 35 | LUMINAL B-like (HER2+) | CDI G3, ER 60%, PR 2%, MIB1 ?, HER2 positive | pT2(25mm)pN0(0/24)M0 | IIA | LUNG | SINGLE LUNG NODULE RESECTION | ER 95%, PR 95%, HER2 positive |
| Patient 3 | 45 | LUMINAL B-like | CLI G3, ER 90%, PR 90%, MIB1 50%, HER2 negative | pT2(multif)pN1(1/15)M0 | IIB | SKIN (Local Relapse) | SKIN PUNCH | ER 90%, PR 60%, HER2 negative |
| Patient 4 | 56 | LUMINAL A-like | CDI G2, ER 95%, PR 95%, MIB1 8%, HER2 negative | pT2pN3(11/13)M1 | IV | BONE, SKIN (Scalp) | SKIN PUNCH | ER 90%, PR 50%, MIB 20%, HER2 negative |
| Patient 5 | 52 | LUMINAL A-like | CDI G2, ER 90%, PR 80%, MIB1 15%, HER2 negative | pT1cpN1(1/19)M0 | IIA | IPSILATERAL AXILLARY LYMPH NODES, BONE, LIVER | IPSILATERAL AXILLARY LYMPH NODES | ER 10%, PR 1%, HER2 negative |
| Patient 6 | 71 | LUMINAL B-like (HER2+) | CDI G3, ER 100%, PR 10%, MIB1 15%, HER2 positive | pT1cpN0M0 | IA | IPSILATERAL SUPRACLAVICULAR LYMPH NODES | IPSILATERAL SUPRACLAVICULAR LYMPH NODES | ER 90%, PR 1%, HER2 positive |
| Patient 7 | 57 | LUMINAL A-like | CDI G3, ER 90%, PR 40%, MIB1 8%, HER2 negative | pT2,pN3(17/33),M1 | IV | CONTRALATERAL AXILLARY LYMPH NODES, BONE | CONTRALATERAL AXILLARY LYMPH NODES | ER 0%, PR 0%, HER2 negative |
| Patient 8 | 47 | LUMINAL A-like | CDI G3, ER 85%, PR 9%, MIB1 16%, HER2 negative | pT1cpN1(2/20)M0 | IIA | CONTRALATERAL AXILLARY LYMPH NODES | CONTRALATERAL AXILLARY LYMPH NODES | ER 100%, PR 100%, HER2 negative |
| Patient 9 | 73 | LUMINAL A-like | CDI G2, ER 100%, PR 90%, MIB1 15%, HER2 negative | pT1cpN0M0 | IA | BONE, LUNG, LIVER, LYMPH NODES | LIVER | ER 85%, PgR 0%, MIB1 10%, HER2 negative |
| Patient 10 | 71 | LUMINAL B-like (HER2+) | CDI G3, ER 15%, PR neg, MIB1 10%, HER2 positive | pT2,pN3(39/39),M0 | IIIC | LYMPH NODES, IPSILATERAL CHEST WALL | IPSILATERAL CHEST WALL | ER neg, PR neg, HER2 positive |
| Patient 11 | 56 | LUMINAL B-like | CDI G2, ER 98%, PR 0%, MIB1 25%, HER2 negative | pT1c(multif),pN0,M0 | IA | IPSILATERAL AXILLARY LYMPH NODES | IPSILATERAL AXILLARY LYMPH NODES | ER 15%, PR neg, MIB1 40%, HER2 negative |
| Patient 12 | 81 | LUMINAL B-like | CLI G3, ER 80%, PR <1%, MIB1 15%, HER2 negative | cT3,cN+,M0 | IIIA | BREAST, LYMPH NODES, BONE, LIVER | IPSILATERAL MASTECTOMY | ER neg, PR neg, MIB1 40%, HER2 negative |
| Patient 13 | 61 | LUMINAL B-like | CLI G3, ER 90%, PR 90%, MIB1 70%, HER2 negative | pT2,pN0(0/19),M0 | IIA | BREAST, IPSILATERAL AXILLARY SOFT TISSUES | IPSILATERAL AXILLARY SOFT TISSUES | ER 50%, PR neg, MIB1 25%, HER2 positive |
| Patient 14 | 48 | LUMINAL B-like | CDI G3, ER 95%, PR 95%, MIB1 80%, HER2 negative | cT3,cN+,M0 | IIIA | BONE, LUNG, LIVER, LYMPH NODES | LIVER | ER 95%, PR 3%, MIB1 30%, HER2 negative |
| Patient 15 | 53 | LUMINAL B-like (HER2+) | CDI G3, ER 90%, PR 30%, MIB1 10%, HER2 positive | pT1c,pN2(6/16),M0 | IIIA | IPSILATERAL BREAST (CUTANEOUS) | IPSILATERAL BREAST SKIN PUNCH | ER 90%, PR neg, MIB1 25%, HER2 positive |
| Patient 16 | 45 | LUMINAL B-like | CDI G3, ER 90%, PR 1%, MIB1 40%, HER2 negative | IBC cT4cN+M0 (right) | IIIB | CONTRALATERAL BREAST, RIGHT CHEST WALL, BONE | RIGHT CHEST WALL | ER 30%, PR neg, MIB1 20%, HER2 negative |
Discordant ER, PR and HER2 reported in red.