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. 2018 Aug 3;9(60):31637–31649. doi: 10.18632/oncotarget.25827

Figure 2. Down-regulation of FGFR1 gene expression radio-sensitizes and increases radio-induced cell death in tumor cells derived from GBM biopsy specimen.

Figure 2

Cells derived from 2 GBM biopsy specimen (GC1 and GC2) were transfected with siFGFR1(11) (GC1FGFR1(-) or GC2FGFR1(-)) or a scramble control (Ctl). (A–B) Cells were analyzed in clonogenic assay as described in “Materials and Methods”. (C–D) 48 h post-irradiation (4 Gy), propidium iodide staining was performed as described in “Materials and Methods” and the DNA content was analyzed by flow cytometry. Percentages of cells in sub-G1 are presented. Quantifications of 3 experiments are presented as means ± SD. ***p < 0.001; ** p < 0.01; * 0.01 < p < 0.05.