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. 2018 Aug 3;9(60):31637–31649. doi: 10.18632/oncotarget.25827

Figure 4. Inhibition of FGFR1 or FOXM1 modifies expression of genes implicated in mesenchymal transition and migration of cells derived from human GBM biopsy specimens.

Figure 4

Cells derived from 2 GBM biopsy specimen (GC1 and GC2) were transfected with siFGFR1(11) (GC1FGFR1(-) or GC2FGFR1(-)) or siFOXM1 (GC1FOXM1(-) or GC2FOXM1(-)) or a scramble control (Ctl). (A) 72 h post-transfection ZEB1, GLI2, TWIST1 expression was analyzed by western-blot in GC1FGFR1(-), GC1FOXM1(-), GC2FGFR1(-), GC2FOXM1(-) and Ctl. Image is representative of 3 independent experiments. β-actin was used as a loading control. (B) Cells were analyzed in migration assay as described in “Materials and Methods”. Quantifications of 3 experiments are presented as means ± SD. ***p < 0.001; **p < 0.01; *0.01 < p < 0.05.