Fig. 5. (a) In vivo photothermal images of the control group with PBS injection and the experimental group with the nanoagent injection for 24 h. (–) no NIR irradiation, (+) NIR irradiation. (b) In vivo T1-weighted MR images of the mice taken before (left) and 24 h post injection (right) of the nanoagent, the red circles highlight the solid tumor. (c) Micrographs of tumor slices with cell nuclei and hypoxia areas stained with DAPI (blue) and hypoxia-probe (green), control group: injected with PBS (i), test group: injected with SiO2@Au@MnO2–DOX/Apt with NIR irradiation (ii). Scale bar: 75 μm. (d) The mice weight change curves of different groups of mice after various treatments are indicated (four mice per group).
