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. 2017 May 10;14(1):22–38. doi: 10.1900/RDS.2017.14.22

Figure 2. Effect of TLA on islet isolation parameters.

Figure 2

The figure shows the effect of TLA on rat pancreas digestion time (A), islet yield (B), viability (C), and graft function of isolated rat islets transplanted beneath the kidney capsule of diabetic nude mice (D). TLA was supplemented at a concentration of 0.25 (n = 5), 1.0 (n = 5) and 2.0 BAEE-U/pancreas combined with 0.4 DMC-U of neutral protease activity and 20 PZ-U of collagenase activity. Nephrectomy (Nx) was performed at day 32 post-transplant as indicated. **p < 0.01, ***p < 0.001 vs. 2.0 BAEE-U.