Table 1. T. gondii proliferation inhibition activity and cytotoxicity of the six identified hits.

Compound	IC50 (μM)a	CV50 (μM)b	SIc
TS2	0.9 ± 0.1	>81	>90
CH2	3.3 ± 0.2	31.5 ± 7.3	9.5
CH3	3.7 ± 0.2	7.8 ± 2.5	2.1
CH9	6.6 ± 1.5	>81	>12.3
DO3	27.7 ± 6.2	>81	>3
AU11	9.9 ± 2.4	>81	>8.2
pyrimethamine	0.4 ± 0.03	>81	>202

^aIC₅₀: concentration (μM) to inhibit 50% of T. gondii proliferation

^bCV₅₀: concentration (μM) to inhibit the viability of 50% of host cells

^cselectivity index: CV₅₀/IC₅₀