Figure 1.

B cell transfer-induced murine model of ischemic Raynaud’s. Progressive ear and tail loss are noted in syngeneic B cell recipients from 70k-immunized HLA-DR4tg B6 mice. In the top three rows, the same mice are shown 7 and 14 days after cell transfer; arrows indicate areas of tissue loss. At the bottom, an additional recipient mouse that lost its tail 14 days after transfer is shown along with the ischemic tail.