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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Arthritis Rheumatol. 2018 Jul 25;70(9):1489–1499. doi: 10.1002/art.40505

Figure 2.

Figure 2

Serum transfer of ischemia phenotype. A. Murine serum transfer from ischemic B cell recipients as in Figure 1 induces dose-dependent tissue loss by 14 days (arrows), not seen with B cell donor sera. B. Human Raynaud’s patient serum transfer (10 microliters) following the same protocol as in A induces progressive ear tissue loss (arrows) from Day 0 to Day 6 to Day 15 in the same mouse, not seen with healthy control human serum. C. Raynaud’s serum transfer induces vascular apoptosis. Mice received human Raynaud’s or healthy control sera. Two weeks later, ear tissue (10×) showed increased TUNEL staining (brown) in the Raynaud’s serum recipient compared to the normal control, prominently near the lumen of blood vessels (arrows).