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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Arthritis Rheumatol. 2018 Aug 6;70(9):1429–1439. doi: 10.1002/art.40521

Figure 5. Inhibitory pathways mediated by PD1/PD-L1 and HVEM/CD160/BTLA were operative in RA patients.

Figure 5

A–B, Proliferation of CD4+ and CD8+ T cells from PB (A) and SF (B) of HD, rRA and nrRA after stimulation in the absence or presence of HVEM:Fc, PD-L1:Fc and their combination. C, Proliferation index calculated according to data from A and B. D, Frequency of CD8+ and CD4+ T cells from SF producing the indicated effector cytokine. Statistical analysis: Student’s paired T test (A–C) and Wilcoxon T test (D). n.s.:not significant.