Table 4.
Summary of cytokine and chemokine biomarkers (mITT)
| Baminercept | Placebo | P value | |
|---|---|---|---|
| BAFF (pg/mL) | |||
| N | 29 | 14 | |
| Week 0 Mean (SE) | 830 (51.7) | 670 (20.4) | |
| Week 24 Mean (SE) | 856 (66.3) | 660 (28.6) | |
| Adjusted Mean (CI) Change | 29.0 (−51.6, 109.6) | −17.6 (−135.7, 100.5) | 0.523 |
| LIGHT (pg/mL) | |||
| N | 26 | 13 | |
| Week 0 Mean (SE) | 513 (170.0) | 305 (129.2) | |
| Week 24 Mean (SE) | 410 (137.4) | 258 (108.0) | |
| Adjusted Mean (CI) Change | −88.0 (−150.2, −25.7) | −76.8 (−165.1, 11.5) | 0.840 |
| IP-10 (pg/mL) | |||
| N | 29 | 14 | |
| Week 0 Mean (SE) | 65 (21.3) | 21 (3.8) | |
| Week 24 Mean (SE) | 49 (12.0) | 24 (3.8) | |
| Adjusted Mean (CI) Change | −9.9 (−16.1, −3.7) | −10.5 (−19.5, −1.5) | 0.907 |
| CXCL13 (pg/mL) | |||
| N | 29 | 14 | |
| Week 0 Mean (SE) | 236 (43.7) | 193 (91.2) | |
| Week 24 Mean (SE) | 127 (26.4) | 191 (88.7) | |
| Adjusted Mean (CI) Change | −104.7 (−154.1, −55.3) | −12.7 (−83.8, 58.5) | 0.038 |
Only subjects with samples available at week 0 and 24 are included.
Abbreviations: BAFF=B cell activating factor; LIGHT=homologous to lymphotoxin, exhibits inducible expression, and competes with HSV glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes; IP-10= Interferon gamma-induced protein 10 (CXCL10) Mean change and 95% CI adjusts for baseline results.