Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 29;8:13025. doi: 10.1038/s41598-018-31328-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The proximal promoter of NEXN is sensitive to myocardin family coactivators. The promoter of NEXN (panel A) contains two CArG-like sequences (pink/red), an MCAT motif (i.e. a motif binding YAP/TEAD, green), a GATA motif (orange), and a glucocorticoid receptor motif (blue). Panel B shows reporter activity after transduction of MRTF-A/MKL1 and myocardin/MYOCD, respectively (N = 9). Combined transduction with MKL1 and LatB treatment, compared to transduction with MKL1 and treatment with DMSO was done in a separate experiment (N = 6), but is summarized in the same graph for brevity. Panel C shows induction of the NEXN mRNA following treatment with TGFβ (N = 6). Corresponding protein data is shown in panels D and E (N = 6). Panels F and G show NEXN mRNA expression at different time points (N = 4) and concentrations (N = 8) of hydrocortisone treatment.