Fig. 2. The effect of curcumin on histamine-induced firing rates in peripheral nerves.

The effect of curcumin was assessed using ex-vivo recordings. Application of histamine (200 μM) evoked discharges of single saphenous nerve fibers, which were inhibited by curcumin (2 μM). Black line indicates histamine treatment, gray line indicates curcumin treatment. In the right panel, each symbol represents the firing rate (number of action potentials/min), while horizontal lines indicate means±SEM. Asterisks indicates a significant difference at p<0.05 (paired t-test).