Fig. 4. A comparison of the relationship between TRPV1 and TRPA1 in the blocking action of curcumin on an itch.

The total number of scratches were observed for 30 min after intradermal injection of histamine, compound 48/80, and chloroquine into WT, KO mice, and KO mice treated with 3 wt.% curcumin. A bar graph shows the total number of scratches as a mean±SEM. Asterisks indicate p<0.05.