Table 3.
Cox regression analysis of risk factors for cancer-related death in lung cancer patients
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HRa (95% CIb) | P-valuec | HRa (95% CIb) | P-valuec | |
| Rab37/SFRP1/Oct4 protein expressiond | ||||
| +/+/− | 1.00 | 1.00 | ||
| Others | 1.87 (0.82–4.26) | 0.137 | 2.13 (0.92–4.96) | 0.079 |
| −/−/+ | 4.28 (1.79–10.3) | 0.001 | 3.09 (1.24–7.74) | 0.016 |
| Age | ||||
| <65 year-old | 1.00 | –f | ||
| ≥65 year-old | 1.35 (0.78–2.32) | 0.282 | –f | –f |
| Gender | ||||
| Female | 1.00 | –f | ||
| Male | 1.73 (1.00–3.01) | 0.052 | –f | –f |
| Smoking habit | ||||
| Non-smoker | 1.00 | –f | ||
| Smoker | 1.57 (0.91–2.70) | 0.102 | –f | –f |
| Typee | ||||
| SCC | 1.00 | –f | ||
| ADC | 0.98 (0.48–2.01) | 0.947 | –f | –f |
| Stage | ||||
| Stage I-II | 1.00 | 1.00 | ||
| Stage III-IV | 2.74 (1.59–4.74) | <0.001 | 0.70 (0.32–1.54) | 0.378 |
| T stage | ||||
| Stage 1–2 | 1.00 | 1.00 | ||
| Stage 3–4 | 2.28 (1.03–5.07) | 0.043 | 1.39 (0.58–3.34) | 0.459 |
| N stage | ||||
| N0 | 1.00 | 1.00 | ||
| ≥N1 | 3.72 (2.18–6.34) | <0.001 | 3.79 (1.98–7.28) | <0.001 |
| M stage | ||||
| M0 | 1.00 | 1.00 | ||
| ≥M1 | 3.94 (1.88–8.28) | <0.001 | 2.98 (1.20–7.41) | 0.019 |
aHR hazard ratio
bCI confidence interval
cBold values indicate statistical significance (P < 0.05)
dPatients were grouped according to Rab37, SFRP1 and Oct4 expression, respectively. +: preserved; −: low expression for Rab37 and SFRP1; +: high; −: normal expression for Oct4
eADC adenocarcinoma, SCC squamous-cell carcinoma
fData were not included in multivariate