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. 2018 Aug 29;9:3503. doi: 10.1038/s41467-018-05992-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — EMT-related gene expression is inversely correlated with tumor purity in UC specimens and likely emanates from stroma. Plot of correlation between a tumor purity and ITA, b tumor purity and EMT-related genes, c tumor purity adjusted ITA and EMT, d EMT-related genes and stromal signature (average of stromal_ESTIMATE gene expression), and e EMT-related genes and average of immune_ESTIMATE gene expression in TCGA UC samples; f Overlap among EMT-related, stromal_ESTIMATE and immune_ESTIMATE gene sets