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. 2018 Aug 29;8:13029. doi: 10.1038/s41598-018-31384-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Workflow for analyzing the accuracy of the applied MRI technique. I For accuracy measurements, a cuboid-shaped Lego phantom (127.8 mm × 95.8 mm × 48.0 mm) was scanned on a 3 Tesla MRI system using a high-resolution 3D sequence. The phantom was placed in a plastic box filled with water and contrast agent before it was scanned in three positions (normal alignment, rotated, rotated and lifted). An exemplary MR image in frontal orientation (according to the blue section planes on the phantom graphics) is shown on the right side. II For each phantom position, the 4 vertices on the top (T1–T4) and the 4 vertices on the bottom (B1–B4) were determined as landmarks on multiplanar reconstructions (MPR) using DICOM Imaging Software (Osirix v.7.0.3). III Based on the landmarks’ coordinates, a total of 96 angles and 96 distances were calculated for each phantom position using a customized software tool.