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. 2018 Aug 23;9:476. doi: 10.3389/fendo.2018.00476

Figure 6.

Figure 6

Effects of long-term l-serine administration on the leptin signaling pathway in aging mice. (A–E) LepRb expression as determined by immunohistochemistry; (F) leptin content in the hypothalamus; (G) relative LepRb mRNA expression; (H,I) relative pSTAT3 protein expression. Aged, untreated control mice; Low-ser, mice fed with 0.1% (wt/vol) l-serine dissolved in the drinking water; Middle-ser, mice fed with 0.2% (wt/vol) l-serine dissolved in the drinking water; High-ser, mice fed with 0.5% (wt/vol) l-serine dissolved in the drinking water. Young, adult male mice at the age of 18 months. Arrow (yellow), expression of LepRb protein; LepRb, leptin receptor. Values are expressed as mean ± SEM, n = 3 for the statistical analysis of western blotting data and n = 8 for the statistical analysis of other data; a, bMeans of the bars with different letters were significantly different among groups (p < 0.05).