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Baseline volumetric changes in brain revealed by voxel-based morphometry (VBM). Overlay of statistical parametric maps in grey matter shows volumetric decreases in bilateral thalamus, in bilateral lingual gyrus extending into the cerebellum, and in the left inferior frontal gyrus in patients compared to control. Overlay of statistical parametric maps are uncorrected P < .001, for illustrative purposes. The colour bar indicates the t score.
