Table 2.

Results of whole brain and region of interest (ROI) analysis using voxel based morphometry (VBM), voxel based cortical thickness (VBCT), and voxel based quantification (VBQ) methods; LT: Light touch score, LEMS: Lower extremity score.

	Brain area	Z-score	P-value (FWE corrected)	Cluster extent	X (mm)	Y (mm)	Z (mm)
Whole brain analysis
VBM (GM)	Left anterior insula	5.01	=0.009	743	−35	30	5
	Bilateral thalamus	4.70	=0.007	780	0	−11	6
	Bilateral anterior cingulate gyrus	4.50	=0.001	1203	−2	35	−15
	Bilateral lingual gyrus extending to cerebellum	5.83	=0.0001	982	2	−62	8
VBCT	Bilateral M1	4.79	=0.039	412	53	11	18
	Bilateral S1	4.84	=0.001	858	−54	−23	50
	Right lingual gyrus extending to Cerebellum	4.06	=0.01	572	14	−80	−15
Region of interest (ROI) analysis in brain
VBM (GM)	Right cerebellum	4.68	=0.0001	1088	24	−74	−18
	M1 representing left leg area	3.96	=0.013	400	−53	−11	32
	Right S1	4.07	=0.032	434	44	−17	42
VBCT	Bilateral cerebellum	4.01	=0.032	259	12	−77	−15
	Right M1 representing right leg	3.51	=0.03	21	5	−33	63
	Left S1	4.85	=0.001	861	−54	−23	50
VBQ (MT, R2*)	Right Cerebellum (MT)	5.58	=0.009	98	24	−80	−24
	Cerebellar vermal lobules VI-VII (MT)	4.11	=0.033	71	3	−74	−20
	Right cerebellum (R2*)	5.02	=0.002	160	24	−87	−26
Baseline predictors of outcome in brain
GM volume & LT score at 12 M	Left cerebellum	4.02	=0.03	326	−14	−93	−30
R2* & LEMS scores at 6 M	Right cerebellum	6.23	=0.002	158	14	−69	−57
R2* & LEMS scores at 12 M	Right cerebellum	5.30	=0.009	117	14	−71	−57