Figure 1.

Humoral response results in IgG formation. Schematic overview of a humoral immune response to recombinant GLA resulting in IgG antibody production. In a classic T cell–dependent immune response, the recombinant human (rh) GLA is processed by antigen-presenting cells (APC) and presented to CD4⁺ T cells, which become activated. Activated T cells, in turn, activate naïve B cells, which maturate into IgG4-secreting plasma cells.