Figure 7.

Vicious circle between CELCs and macrophages. (A) CELCs secrete L-LA to promote the differentiation of macrophages. (B) L-LA induced macrophages to upregulate ARG1 and activate the arginine-polyamine metabolic pathway. (C) Polyamine stimulates CLEC proliferation. (D) ARG1 stimulates CLEC proliferation (requires further verification). (E) Proliferative CLECs produce more L-LA in the microenvironment. (F) Nor-NOHA can disrupt the synthesis of polyamine. MACs, macrophages; L-LA, L–lactic acid.