Figure 2.

Yasue staining evidences the development of murine Randall plaque with age. (A–E) Representative papilla from Abcc6^−/− mice at various ages exhibit increasing Yasue staining with aging, which was absent in control mice Magnification, ×100. (F) The percentage of papillary tissue calcification was assessed by morphometry in 15 wild-type (WT) and 17 Abcc6^−/− mice. At 24 months, calcified surface was significantly increased in Abcc6^−/− mice (n=4 Abcc6^−/− mice kidneys and n=5 WT mice kidneys). *P=0.01.