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. 2018 Jul 10;29(9):2337–2347. doi: 10.1681/ASN.2017101148

Figure 7.

Figure 7.

Transgenic (tg) ABCC6 expression protects Abcc6−/− mice against kidney calcification. (A) Expression of the functional human ABCC6 protein in Abcc6−/− mice protected against papillary calcification (Yasue staining). Magnification, ×100. (B) Expression of the pseudoxanthoma elasticum–causing ABCC6 mutant protein (R1314W) did not prevent the development of calcifications in the papilla, which was similar to that observed in Abcc6−/− mice (Yasue staining). Magnification, ×400. (C) The percentage of papillary tissue calcification was assessed by morphometry in five Abcc6−/− tg ABCC6 mice and three Abcc6−/− tg R1314W mice. At 18 months of age, calcified surface was significantly decreased in Abcc6−/− tg ABCC6 mice. *P=0.02.