. 2018 Aug 10;10(8):1063. doi: 10.3390/nu10081063

Table 3.

Selected discriminating metabolites in OPLS-EP models.

	Models
	VE ¹ Breakfast		LOV ² Breakfast		OM ³ Breakfast		LOV vs. VE Breakfast				LOV vs. OM Breakfast
Characteristic foods	Soy-yoghurt, cashew butter, lentils		Yoghurt, hard cheese, cottage cheese		Liver pâté, smoked ham, egg
Metabolite	Δconc.	p-value ⁴	Δconc.	p-value	Δconc.	p-value	LOV Δconc.	VE Δconc.	p-value	Fold change	LOV Δconc.	OM Δconc.	p-value	Fold change
3-Hydroxyisobutyrate			↑	0.0001	↑	0.0004	↑		<0.0001	1.83	↑		0.004	1.28
Acetate	↓	0.0009	↓	<0.0001	↓	0.0002
Acetoacetate							↑		<0.0001	1.45
Acetone	↓	0.02
Alanine	↑	0.0004									↑		0.03	1.11
Glucose (alfa, beta)	↓	0.03	↓	0.0006
Arginine & Lysine ⁵	↑	0.003	↑	<0.0001	↑	0.0002
Ascorbate												↑	0.02	0.88
Asparagine	↑	0.02
Betaine	↑	0.0003			↑	<0.0001						↑	0.02	0.84
Carnitine & Acetoacetate ⁵			↑	<0.0001	↑	0.0002	↑		<0.0001	1.24	↑		0.007	1.18
Choline					↑	0.0001						↑	0.003	0.80
Creatinine	↓	0.009
Creatinine & Creatine & Creatine phosphate ⁵	↓	0.004					↑		<0.0001	1.12		↑	0.003	0.93
Isoleucine					↑	0.0001	↑		<0.0001	1.21		↑	0.08	0.90
Lactate											↑		0.06	1.22
Leucine	↓	0.05					↑		<0.0001	1.31
Leucine & Arginine ⁵	↓	0.09	↑	0.002	↑	0.002	↑		<0.0001	1.48
Lipids/FFA	↑	<0.0001			↑	0.002		↑	<0.0001	0.69		↑	0.003	0.76
Lysine					↑	0.0002	↑		<0.0001	1.51		↑	0.3	0.94
Mannose	↓	0.0004	↓	<0.0001	↓	<0.0001
Methionine	↓	0.001			↑	0.0002	↑		<0.0001	1.65
myo-Inositol	↑	0.0007			↑	0.0006
N-Acetylcysteine & Proline & Glutamate ⁵			↑	<0.0001			↑		<0.0001	1.37	↑		0.005	1.37
O-Phosphocholine & 3-Hydroxybutyrate ⁵	↓	0.005
Ornithine	↑	0.0001	↑	<0.0001	↑	0.0001
Proline			↑	<0.0001	↑	0.0001	↑		<0.0001	1.41	↑		0.003	1.29
Proline & Glutamate & Unknown ⁵	↑	0.1	↑	<0.0001	↑	0.0001	↑		<0.0001	1.76	↑		0.003	1.48
Propylene glycol			↑	<0.0001			↑		0.0004	1.42	↑		0.02	1.38
Pyruvate											↑		0.2	1.28
Serine & Tyrosine ⁵												↑	0.001	0.86
Succinic acid	↓	0.0005									↑		0.2	1.26
Threonine	↓	0.004					↑		<0.0001	1.33
Tyrosine			↑	<0.0001	↑	0.0003	↑		<0.0001	1.42	↑		0.005	1.13
Valine			↑	<0.0001		0.0001	↑		<0.0001	1.22

¹ Vegan breakfast Δ in concentration between fasting and postprandial (3 h) state. ² Lacto-ovo vegetarian breakfast Δ in concentration between fasting and postprandial (3 h) state. ³ Omnivore breakfast Δ in concentration between fasting and postprandial (3 h) state. ⁴ p-value calculated using Wilcoxon signed ranked test. ⁵ Overlapping metabolites. ↓ indicates decreace in concentration of discriminating metabolites in OPLS-EP models. ↑ indicates in concentration of discriminating metabolites in OPLS-EP models