Table 1.
Mechanism of PAX2 and PAX8 regulation in specific cancer types.
| Cancer Type | PAX2 Regulation | PAX8 Regulation | References |
|---|---|---|---|
| HGSC | Transcriptional downregulation | No change | [39] |
| Endometrial | Promoter hypomethylation | No change | [62] |
| Thyroid | No change | PAX8-PPARγ1 fusion | [68] |
| Renal | Promoter hypomethylation | Increased protein levels | [63,73] |
| Wilms tumor | Transcriptional upregulation | Transcriptional upregulation | [74,75] |
| Breast | Transcriptional upregulation | No change | [76] |
| Glioma | Transcriptional upregulation | Transcriptional upregulation | [77,78] |