Table 2.
Rate ratios for failure of assisted reproduction technique (ART) outcomes.
| Number of High-Quality Oocytes (Adjusted * Median, 95% CI) | Implantation | ARR (95% CI) |
Clinical Pregnancy | ARR (95% CI) | Live Birth | ARR (95% CI) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Failure n = 46 (13.6%) |
Success n = 293 (86.4%) |
Failure n = 229 (67.6%) |
Success n = 110 (32.4%) |
Failure n = 257 (75.8%) |
Success n = 82 (24.2%) |
|||||||||||
| Women | ||||||||||||||||
| Caffeine intake | n | % | n | % | n | % | n | % | n | % | n | % | ||||
| First tertile | 4.8 (4.0–5.7) | 14 | 30.4 | 100 | 34.1 | 1 | 74 | 32.3 | 40 | 36.4 | 1 | 84 | 32.7 | 30 | 36.6 | 1 |
| Second tertile | 4.6 (3.9–5.4) | 20 | 43.5 | 96 | 32.8 | 1.34 (0.64–2.79) | 84 | 36.7 | 32 | 29.1 | 1.07 (0.76–1.50) | 95 | 37.0 | 21 | 25.6 | 1.09 (0.79–1.50) |
| Third tertile | 5.3 (4.5–6.1) | 12 | 26.1 | 97 | 33.1 | 0.90 (0.38–2.10) | 71 | 31.0 | 38 | 34.6 | 1.00 (0.70–1.43) | 78 | 30.3 | 31 | 37.8 | 0.99 (0.71–1.40) |
| >90 percentile § | 5.1 (3.8–6.7) | 5 | 10.9 | 29 | 9.9 | 0.58 (0.16–2.04) | 23 | 10.0 | 11 | 10.0 | 0.96 (0.51–1.80) | 24 | 9.3 | 10 | 12.2 | 0.99 (0.54–1.84) |
| Men | ||||||||||||||||
| Caffeine intake | ||||||||||||||||
| First tertile | - | 12 | 26.1 | 100 | 34.1 | 1 | 71 | 31.0 | 41 | 37.3 | 1 | 83 | 32.3 | 29 | 35.4 | 1 |
| Second tertile | - | 22 | 47.8 | 91 | 31.1 | 1.64 (0.78–3.44) | 76 | 33.2 | 37 | 33.6 | 1.01 (0.72–1.42) | 88 | 34.2 | 25 | 30.5 | 1.02 (0.75–1.41) |
| Third tertile | - | 12 | 34.8 | 102 | 34.8 | 0.78 (0.32–1.87) | 82 | 35.8 | 32 | 29.1 | 1.07 (0.76–1.52) | 86 | 33.5 | 28 | 34.1 | 1.00 (0.72–1.40) |
| >90 percentile § | - | 4 | 8.7 | 35 | 12 | 0.73 (0.17–3.16) | 27 | 11.8 | 12 | 10.9 | 1.12 (0.59–2.14) | 29 | 11.3 | 10 | 12.2 | 0.98 (0.54–1.83) |
| Combined intake (W-M) | ||||||||||||||||
| Low-low | - | 14 | 30.4 | 81 | 27.6 | 1 | 64 | 28.0 | 31 | 28.2 | 1 | 71 | 27.6 | 24 | 29.3 | 1 |
| Low-high | - | 10 | 21.7 | 65 | 22.2 | 0.79 (0.34–1.85) | 56 | 24.4 | 19 | 17.3 | 1.03 (0.71–1.50) | 62 | 24.1 | 13 | 15.8 | 1.09 (0.76–1.55) |
| High-low | - | 12 | 26.1 | 61 | 20.8 | 1.22 (0.53–2.78) | 48 | 21.0 | 25 | 22.7 | 0.95 (0.64–1.42) | 57 | 22.2 | 16 | 19.5 | 1.06 (0.73–1.54) |
| High-high | - | 10 | 21.7 | 86 | 29.4 | 0.60 (0.24–1.48) | 61 | 26.6 | 35 | 31.8 | 0.89 (0.61–1.30) | 67 | 26.1 | 29 | 35.4 | 0.93 (0.65–1.33) |
The final model included women’s age class and college degree, smoking habits, calorie and alcohol intake for both men and women, previous ART cycles, and partner’s caffeine intake. ARR: adjusted rate ratio; CI: confidence interval; * for women’s age class and education, smoking habits, calorie and alcohol intake; § reference category: <10 percentile; W-M: women-men.