Table 4.
Endometriosis and endometriosis-associated ovarian cancer cell lines.
| Cell Line | Original Derivation | Putative Histotype by Molecular Studies | Genetic Mutations | Genetic Gains | Ref. |
|---|---|---|---|---|---|
| 11Z | Red peritoneal endometriotic lesion | Benign | Unknown | Unknown | [183] |
| 12Z | Red peritoneal endometriotic lesion | Benign (epithelial-like) | Unknown | Unknown | [183] |
| EEC16 | Benign endometriotic lesion (epithelial-like) | Benign | Unknown | Unknown | [184] |
| EMosis-CC/TERT | Benign endometriotic lesion (epithelial-like) | Benign | Unknown | Unknown | [185] |
| 22B | Red peritoneal endometriotic lesion (Stromal/fibroblast-like) | Benign | Unknown | Unknown | [183] |
| Hs 832(C).T (CRL-7566) |
Benign endometriotic ovarian cyst | Benign | Unknown | Unknown | ATCC |
| OVTOKO | Clear-cell (spleen metastasis) | Clear-cell | None | ERRB2, HNF1B, MET, PPM1D, STAT3, TP53, YAP1, ZNF217, CDKN2A, CDKN2B | [177,178,179,182] |
| OVMANA | Clear-cell (primary tumor) | Clear-cell | BRCA2, PIK3CA, ARID1A | ARID1A, MET, PPM1D, TP53, ZNF217 | [178,179,182,186] |
| TOV21G | Clear-cell (primary tumor) | Clear-cell | KRAS, PTEN, PIK3CA, CTNNB1, ARID1A, TPX2 | [178,179,180,181,182,187] | |
| RMG-1 | Clear-cell (ascites) | Clear-cell | TP53 * | ERBB2 | [178,179,182,188] |
| RMG-2 | Clear-cell | Clear-cell | PPP2R1A, ARID1A | ERBB2, HNF1B, MET, PIK3CA, PPM1D, STAT3, ZNF217, CDKN2A, CDKN2B | [179] |
| OCC1 | Clear-cell | Clear-cell | [189] | ||
| JHOC-5 | Clear-cell (pelvic metastasis) | Clear-cell | ARID1A, ERBB2, HNF1B, MET, PIK3CA, PPM1D, STAT2, ZNF217, CDKN2A, CDKN2B | [178,179,182,190] | |
| JHOC-7 | Clear-cell | Clear-cell | PIK3CA | ARID1A, HNF1B, PIK3CA, PPM1D, STAT3, ZNF217 | [179] |
| JHOC-9 | Clear-cell | Clear-cell | PTEN, ARID1A | HNF1B, ZNF217 | [179] |
| ES2 | Poorly differentiated clear-cell (primary tumor) | Endometrioid/Clear-cell | BRAF, TP53, APC, MYC | [178,179,180,181,182,191] | |
| OVISE | Clear-cell (pelvic metastasis) | Endometrioid/Clear-cell | ARID1A | [177,178,179,182] | |
| OVSAYO | Clear-cell | Serous | TP53 | [179] | |
| TOV112D | Endometrioid (primary tumor) | Endometrioid | CTNNB1, TP53 | [179,180,181,182,187] | |
| OVK18 | Endometrioid (ascites) | Endometrioid | TP53, PTEN, KRAS, ARID1A | [178,182,192] | |
| SNU-251 | Endometrioid | Endometrioid | BRCA1 | [193] | |
| 2008 | Endometrioid | Atypical non-serous | TP53 | [179] | |
| IGROV1 | Endometrioid with serous/clear cell (primary tumor) | Endometrioid/Clear-cell | PTEN, TP53, ARID1A, BRCA1, BRCA2, PIK3CA, TPX2 | [178,179,180,182,194] | |
| 59M | Endometrioid with clear cell (ascites) | Endometrioid/Clear-cell | TP53 | MYC | [178,180,182,193,195] |
| COV362 | Endometrioid (pleural effusion) | Serous | TP53, BRCA1, RB1 *, EGFR, APC | MYC | [178,180,182,196] |
| A2780 | Unknown adenocarcinoma | Endometrioid | PTEN, ARID1A, PIK3CA, BRAF | [178,179,180,181,182,197] | |
| HEYA8 | Moderately differentiated papillary serous (peritoneal metastasis) | Unlikely serous | KRAS, BRAF | [178,179,182,198] | |
| SKOV3 | Well differentiated, adenocarcinoma (ascites) | Endometrioid/Clear-cell | PIK3CA, ARID1A | ERBB2 | [178,179,180,181,182,199] |
* Homozygous deletion.