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. 2018 Aug 15;8(8):75. doi: 10.3390/bs8080075

Figure 6.

Figure 6

(a) Scatter plot of differential relative expression of miR27a in peripheral blood of ASD subjects compared to control subjects. Results expressed as mean ± standard error. t-Test analysis; * p < 0.05. (b) mRNA validates targets for miR27a selected in miRBase and respective proteins clusters that can be involved in ASD. Proteins involved in epigenetic regulation: SP4 (Sp4 transcription factor); SP3 (Sp3 transcription factor); WDR77 (WD repeat domain 77); RUNX1 (runt-related transcription factor 1); MYT1 (myelin transcription factor 1); SP1 (Sp1 transcription factor); FOXO1 (forkhead box O1); PAX3 (paired box 3); NFE2L2 (nuclear factor (erythroid-derived 2)-like 2); HIPK2 (homeodomain interacting protein kinase 2); ZBTB10 (zinc finger and BTB domain containing 10). Proteins involved in cell cycle: PHB (prohibitin), WEE1 (WEE1 homolog). Others: APC (adenomatous polyposis coli), MMP13 (matrix metallopeptidase 13 (collagenase 3)); MSTN (myostatin); EGFR (epidermal growth factor receptor); FBXW7 (F-box and WD repeat domain containing 7); IGF1 (insulin-like growth factor 1); PDS5B (regulator of cohesion maintenance, homolog B); THRB (thyroid hormone receptor, beta); ABCA1 (ATP-binding cassette, sub-family A (ABC1), member 1); SPRY2 (sprouty homolog 2).