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. 2018 Aug 16;10(8):273. doi: 10.3390/cancers10080273

Table 3.

Summary of RKIP/PEBP1 interactions.

Family Protein Name Main Function
WD Repeat
Domain
WDR45 WD Repeat Domain 45 Frequently mutated in lung adenocarcinomas [15].
WIPI1 WD Repeat Domain, Phosphoinositide Interacting 1 High expression is associated with survival in hepatocellular carcinoma patients [16].
PI3K PIK3C3 Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 Promote cancer growth through p62 [17].
PIK3CB Phosphatidylinositol-4, 5-Bisphosphate 3-Kinase Catalytic Subunit Beta Mediates cancer metastasis [18].
TBC TBC1D5 TBC1 Domain Family Member 5 Reduced copy number in breast cancer [19].
TBC1D25 TBC1 Domain Family Member 25
Other TOLLIP Toll Interacting Protein Hypermethylated in response to sex hormones in prostate cancer cells [20].
TGFBR1 Transforming Growth Factor Beta Receptor 1 Multiple polymorphisms are associated with cancer development [21].