Table 3.
Family | Protein | Name | Main Function |
---|---|---|---|
WD Repeat Domain |
WDR45 | WD Repeat Domain 45 | Frequently mutated in lung adenocarcinomas [15]. |
WIPI1 | WD Repeat Domain, Phosphoinositide Interacting 1 | High expression is associated with survival in hepatocellular carcinoma patients [16]. | |
PI3K | PIK3C3 | Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 | Promote cancer growth through p62 [17]. |
PIK3CB | Phosphatidylinositol-4, 5-Bisphosphate 3-Kinase Catalytic Subunit Beta | Mediates cancer metastasis [18]. | |
TBC | TBC1D5 | TBC1 Domain Family Member 5 | Reduced copy number in breast cancer [19]. |
TBC1D25 | TBC1 Domain Family Member 25 | ||
Other | TOLLIP | Toll Interacting Protein | Hypermethylated in response to sex hormones in prostate cancer cells [20]. |
TGFBR1 | Transforming Growth Factor Beta Receptor 1 | Multiple polymorphisms are associated with cancer development [21]. |