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. 2018 Aug 9;10(8):417. doi: 10.3390/v10080417

Figure 2.

Figure 2

Maximum likelihood phylogenetic tree of the hemagglutinin-esterase (HE) gene of 115 influenza C viruses circulating between 1947 and 2016. The coding region without a signal peptide was used for the analysis, corresponding to nucleotide positions 64 to 1989 of the HE gene. Branches of each genetic lineage are colored orange for the C/Mississippi lineage, purple for the C/Aichi lineage, gray for the C/Taylor lineage, green for the C/Yamagata lineage, blue for the C/Kanagawa lineage, and red for the C/Sao Paulo lineage. Strains that were used for the antigenic analysis presented in Table 5 are shown as names and GenBank/DDBJ accession numbers.