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Localization of the action of DUBs in the ubiquitination process. Ubiquitination is catalyzed by three types of enzymes: E1, E2, E3. It is a reversible reaction. DUBs process ubiquitin chains at three level: (A) For the generation of ubiquitin monomers from a ubiquitin precursor; (B) for the selective removal of ubiquitin moieties on ubiquitinated proteins; and (C) for the recycling of ubiquitin from protein degraded by the proteasome.
