Table 5.
Rates of acidosis by risk factor and treatment group.
| Metformin only | Other antihyperglycemic medications | No T2DM medications | Total | |
|---|---|---|---|---|
| N | 9/24,936 | 10/15,059 | 168/92,785 | 187/132,780 |
| Acidosis risk factors | ||||
| Age ⩾80 years | 0/134 | 0/147 | 11/1939 | 12/2221 |
| Chronic obstructive pulmonary disease | 0/1443 | 1/934 | 46/6761 | 48/9139 |
| Hepatic dysfunction | 0/37 | 0/109 | 2/297 | 3/444 |
| Alcohol abuse | 0/36 | 0/39 | 2/206 | 2/281 |
| Heart failure | 0/275 | 0/399 | 31/2579 | 31/3253 |
| Renal insufficiency | 0/68 | 0/234 | 30/1419 | 31/1722 |
| History of acidosis | 0/3 | 0/4 | 3/41 | 3/48 |
| Composite risk score | ||||
| Composite score = 0 | 9/23,066 | 9/13,480 | 81/81,631 | 99/118,177 |
| Composite score = 1 | 0/1752 | 1/1337 | 61/9398 | 62/12,487 |
| Composite score = 2 | 0/110 | 0/203 | 16/1466 | 16/1779 |
| Composite score = 3 | 0/8 | 0/34 | 8/251 | 8/293 |
| Composite score = 4 | 0/0 | 0/4 | 2/36 | 2/40 |
| Composite score = 5 | 0/0 | 0/1 | 0/3 | 0/4 |
T2DM, type 2 diabetes mellitus.