Table 1.

Diagnostic criteria for pediatric GHD²³

Data Type	Possible Findings
Clinical and historical	• Neonatal hypoglycemia • Prolonged hyperbilirubinemia or jaundice • Microphallus • Traumatic delivery • Signs of an intracranial lesion • History of cranial irradiation • History of head trauma • Family history of GHD • Craniofacial midline abnormalities • Other signs of pituitary dysfunction
Auxological	• Growth failure  ○ Height more than 3 SDs below the mean for age  ○ Predicted height a more than 1.5 SDs b below midparental height c  ○ Slow or slowing growth velocity
Radiographic	• Decreased bone age on plain radiographs • Pituitary or midline abnormalities on MRI
Biochemical	• Low (<10 µg/L) serum GH concentration after provocation testing • Abnormal genetic testing

GH, growth hormone; GHD, growth hormone deficiency; MRI, magnetic resonance imaging.

^aCalculating predicted height: Extrapolate current height percentile to 19 years of age.⁵⁸

^b1 SD = 4.25 cm; 1.5 SD = 6.375 cm; 2 SD = 8.5 cm.⁵⁸

^cCalculating midparental height: (Average of mother’s and father’s height) − 13 cm (for girls) or + 13 cm (for boys).⁵⁸