Figure 2.

VE821 potentiates gemcitabine, irrespective of p53 status, but not nontumourigenic immortalised breast cells. Cells were seeded into 6-well plates and allowed to adhere for 24 h. Following 24 h co-exposure to gemcitabine alone (filled circles, solid line) or gemcitabine + 1 µM VE-821 (open circles, dashed line) cells were counted and reseeded at low density for colony formation. Colonies were allowed to grow for 2 weeks before being fixed, stained, and counted. Data are the mean + SEM of 3 individual experiments.