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. 2018 Aug 10;10(8):269. doi: 10.3390/cancers10080269

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Aberrant expression of SOD2 correlates with disease progression, and SOD2-induced down-regulation of hsa-miR-324 facilitates poor prognosis. (A) Representative IHC images of differential SOD2 protein expression in non-tumor, stages I–IV and metastatic colon cancer tissue samples (n = 118). (B) Box and whiskers graph of the expression (Q-score) of SOD2 in stages I–IV and metastatic colon cancer tissue samples, compared to its expression in normal tissues. (C) A bivariate fit of SOD2 and hsa-miR-324 gene expression using data from the TCGA Colon Cancer (COAD) cohort dataset, TCGA. COAD. sampleMap/HiSeqV2, based on the gene-level transcription estimates, as in log2(x + 1) transformed RNA-Seq by Expectation–Maximization (RSEM) normalized count. Kaplan-Meier plots of the (D) SOD2 and (E) hsa-miR-324 differential expression-based overall survival rates of same TCGA Colon Cancer (COAD) cohort. * p < 0.05, ** p < 0.01, *** p < 0.001.

Aberrant expression of SOD2 correlates with disease progression, and SOD2-induced down-regulation of hsa-miR-324 facilitates poor prognosis. (A) Representative IHC images of differential SOD2 protein expression in non-tumor, stages I–IV and metastatic colon cancer tissue samples (n = 118). (B) Box and whiskers graph of the expression (Q-score) of SOD2 in stages I–IV and metastatic colon cancer tissue samples, compared to its expression in normal tissues. (C) A bivariate fit of SOD2 and hsa-miR-324 gene expression using data from the TCGA Colon Cancer (COAD) cohort dataset, TCGA. COAD. sampleMap/HiSeqV2, based on the gene-level transcription estimates, as in log2(x + 1) transformed RNA-Seq by Expectation–Maximization (RSEM) normalized count. Kaplan-Meier plots of the (D) SOD2 and (E) hsa-miR-324 differential expression-based overall survival rates of same TCGA Colon Cancer (COAD) cohort. * p < 0.05, ** p < 0.01, *** p < 0.001.