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. 2018 Jul 27;10(8):982. doi: 10.3390/nu10080982

Figure 2.

Figure 2

Effects of menaquinone-4 and rifampicin on the expression of genes encoding drug metabolizing proteins in the liver of wild-type and hPXR mice. Rifampicin (Rif; 50 mg/kg of body weight) was given by oral gavage to hPXR female mice (A). Menaquinone-4 (MK-4; 100 mg/kg of body weight) was given by oral gavage to hPXR (B) and wild-type (C) female mice. After 6 h, mRNA levels of genes that encode drug metabolizing proteins were measured by quantitative RT-PCR. The relative mRNA levels were normalized to the amount of eukaryotic translation elongation factor 1α1 mRNA. Data are expressed as the mean ± SEM, n = 4–5. $ p < 0.01, * p < 0.05, compared to control groups.